Effect of estrogen signaling in CD8 T cell mediated antiviral response

Abstract Estrogen, the major female sex hormone has been linked with immune response disparity between males and females. However, exact mechanism by which estrogen impacts our ability to fight viral infection development of immunologic memory remains unknown. CD8 T cells represent primary protective against viruses cancer. Here we aim understand how cell mediated antiviral is regulated estrogen. Systemic LCMV in ovariectomized mice generated lower virus-specific compared sham surgery controls. To check if this reduction intrinsic, I a transgenic receptor-α deficient mouse line (ESR1 KO). Using co-adoptive transfer model, differentiation ESR1 KO control both systemic local influenza infection. The lack signaling resulted reduced abundance effector context infections. also displayed cytotoxic ability. In vitrostudies revealed that expansion was primarily impacted signaling, whereas activation cellular apoptosis remain unchanged. Altogether, suggests crucial role steroid initial differentiation, significant ramification for generation responses pathological or physiological deficiency. Supported grants from Searle Scholars Foundation, NIH 2P20GM109035, P20GM121298, T32HL134625, T32GM136566